ajpgi.physiology.orgAmerican Journal of Physiology-Gastrointestinal and Liver Physiology

Login to your account Institutional Login Sign In / Register PHYSIOLOGY.ORGClose Drawer Menu Open Drawer Menu Home Journals AJP-Cell AJP-Endo AJP-GI AJP-Heart AJP-Lung AJP-Regu AJP-Renal AJP (1898-1976) Function - coming soon J Appl Physiol J Neurophysiol Physiol Genomics Adv Physiol Educ Physiology Physiol Rev PHYSIOL REP COMPR PHYSIOL APSselect All journals This Journal Quick Search anywhere Search all content Search Advanced Search Quick Search in Journals Search all content Search Advanced Search Advanced Search 0 Sign inClose Drawer Menu Open Drawer Menu Home COLLECTIONS COVID-19 Cross-Journal AJP-CELL AJP-ENDO AJP-GI AJP-HEART AJP-REGU JAPPL JN PG ADVANCES APS LEGACY APSSELECT This Month’s Selections About INFORMATION For Authors For Reviewers For Librarians For Advertisers For Media/Public For APS Members OTHER PUBLICATIONS Books The Physiologist Magazine ABOUT APS Publications American Physiological Society SUBMIT SUBSCRIBE HELPHome Issues Collections Information About Editor-in-Chief Nigel Bunnett Information for Authors TOC alerts RSS Feed Twitter Facebook LinkedIn Current issue April 2020; volume 318, issue 4 THEME Microbiome and Host Interactions The microbiome-adipose tissue axis in systemic metabolism Patrick Lundgren and Christoph A. Thaiss 2020 Mar 24 : G717-G724 https://doi.org/10.1152/ajpgi.00304.2019 MINI REVIEW Microbiome and Host Interactions Perturbed mitochondrial dynamics, an emerging aspect of epithelial-microbe interactions Derek M. McKay, Nicole L. Mancini, Jane Shearer, Timothy Shutt 2020 Mar 30 : G748-G762 https://doi.org/10.1152/ajpgi.00031.2020 RESEARCH ARTICLES Epithelial Biology and Secretion Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus Leandi Krüger, Tiffany A. Pridgen, Ellie R. Taylor, Katherine S. Garman, Anthony T. Blikslager 2020 Mar 20 : G613-G623 https://doi.org/10.1152/ajpgi.00086.2019 This research is the first to describe the presence of anion channels ClC-2 and CFTR localized to the basal epithelia of porcine esophageal mucosa and the esophageal submucosal glands. In the setting of ex vivo acid exposure, the ClC-2 agonist lubiprostone reduced acid-related injury and enhanced recovery of the epithelial barrier. This work may ultimately provide an alternate mechanism for treating gastresophageal reflux disease. Epithelial Biology and Secretion Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions Krishnan MohanKumar, Kopperuncholan Namachivayam, Nithya Sivakumar, Natascha G. Alves, Venkataramana Sidhaye, Jayanta K. Das, Yerin Chung, Jerome W. Breslin, Akhil Maheshwari 2020 Mar 24 : G705-G716 https://doi.org/10.1152/ajpgi.00324.2019 This research article shows that newborn infants with severe anemia show an age-related susceptibility to developing increased intestinal permeability to ingested macromolecules. This abnormal permeability develops because of abnormalities in intestinal epithelial junctions caused by a deficiency of the molecule E-cadherin in epithelial cells. The deficiency of E-cadherin is caused by destabilization of its mRNA precursor because of increased expression and binding of another molecule, the microRNA let-7e-5p, to the E-cadherin mRNA. See full Table of Contents Editor-in-Chief Nigel Bunnett Calls for Papers Information for Authors TOC alerts RSS Feed Twitter Facebook LinkedIn Video Abstracts Skip slideshow Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome – Miousse et al. (2020); 10.1152/ajpgi.00351.2019 Enterotoxigenic Escherichia coli LT inhibits intestinal ascorbic acid uptake – Subramenium et al. (2019); 10.1152/ajpgi.00259.2018 Muscarinic suppression of ATP-sensitive K + channels mediated by the M 3 /G q/11 /phospholipase C pathway contributes to mouse ileal smooth muscle contractions – Wang et al. (2018); 10.1152/ajpgi.00069.2018 A novel bioluminescence-based method to investigate uptake of bile acids in living cells – Ticho et al. (2018); 10.1152/ajpgi.00133.2018 Effect of Lactobacillus reuteri is mediated by TLR2 – Hoang et al. (2018) - Hoang et al. (2017); 10.1152/ajpgi.00084.2017 Mucosal gene expression in irritable bowel syndrome with constipation – Videlock et al. (2018); 10.1152/ajpgi.00288.2017 Visceral Hypersensitivity Induced by Optogenetic Activation of the Amygdala in Conscious Rats – Johnson et al. (2017); 10.1152/ajpgi.00370.2017 Image of the Week Fig. 2 from Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of postoperative ileus Read the article Calls for Papers Cellular Organelle Interactions in Homeostasis and Disease Deadline: April 30, 2020 Neural Development of the GI Tract Deadline: April 30, 2020 The Physiology of Immune Therapies and Their Application in Treating Gastrointestinal Cancers Deadline: April 30, 2020 Microbially Generated Metabolites in the Gut Ecosystem and Their Interface With Host Physiology Deadline: April 30, 2020 Extracellular Vesicles in Homeostatic and Disease States of Digestive System Deadline: April 30, 2020 Announcements FlexSubmit Now Available for All Journals 2018 Impact Factors Released for APS Journals Browse AJP-GI subject collections Newly published Research Reviews Editorials Articles in Press 30 Mar 2020 Pregnancy facilitates maternal liver regeneration after partial hepatectomy 30 Mar 2020 ROCK1 inhibitor stabilizes E-cadherin and improves barrier function in experimental necrotizing enterocolitis 30 Mar 2020 Signaling through the interleukin-4 and interleukin-13 receptor complexes regulates cholangiocyte TMEM16A expression and biliary secretion 24 Mar 2020 Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions 24 Mar 2020 Organ-specific lymphatics play distinct roles in regulating HDL trafficking and composition 30 Mar 2020 Perturbed mitochondrial dynamics, an emerging aspect of epithelial-microbe interactions 24 Mar 2020 The microbiome-adipose tissue axis in systemic metabolism 4 Mar 2020 Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy 4 Mar 2020 Vitamin D signaling maintains intestinal innate immunity and gut microbiota: potential intervention for metabolic syndrome and NAFLD 16 Jan 2019 Introduction to...